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Article

Both R5 and X4 human immunodeficiency virus type 1 variants persist during prolonged therapy with five antiretroviral drugs.

Journal of virology - 1 Mar 2002

van Rij Ronald P, Visser Janny A, van Praag Rieneke M E, Rientsma Ronald, Prins Jan M, Lange Joep M A, Schuitemaker Hanneke

Abstract excerpt

A viral reservoir of human immunodeficiency virus type 1 (HIV-1)-infected, resting CD4(+) T cells persists despite suppression of plasma viremia by combination antiretroviral therapy. In a longitudinal analysis of three patients treated with a five-drug regimen, both R5 and X4 HIV-1 variants persisted in the cellular reservoir for up to 3 years.

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Identifiers

PMID: 11861873
DOI: 10.1128/jvi.76.6.3054-3058.2002
PMCID: PMC136002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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