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Article

Roles of the intramolecular regions of FE65 in its trans-accumulation and in p53 stabilization in the nuclear matrix of osmotically stressed cells.

FEBS letters - 19 Feb 2010

Kawai Tomoko, Nakaya Tadashi, Suzuki Toshiharu

Abstract excerpt

The neural adaptor protein FE65 interacts with the amyloid beta-protein precursor (APP). In osmotically stressed cells, the membrane APP-tethered FE65 is released into the cytoplasm and translocates to the nuclear matrix, where it stabilizes p53 via a non-canonical pathway. In this study, we foun...

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Source

Identifiers

PMID: 20036665
DOI: 10.1016/j.febslet.2009.12.040

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20036665-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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