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Article

Effect of oxidative stress on DNA damage and beta-amyloid precursor proteins in lymphoblastoid cell lines from a Nigerian population.

Annals of the New York Academy of Sciences - 1 Jan 1999

Lahiri D K, Xu Y, Klaunig J, Baiyewu O, Ogunniyi A, Hall K, Hendrie H, Sahota A

Abstract excerpt

The epsilon 4 allele of apolipoprotein E (APOE) is strongly associated with late-onset Alzheimer's disease (AD) in Caucasian populations, but our studies suggest that APOE epsilon 4 is not a risk factor for AD in Nigerian blacks and is a weak risk factor in African-Americans. The prevalence of AD is lower in Nigerians than in African-Americans. Increased oxidative damage to macromolecules in brain tissue by...

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Identifiers

PMID: 10672260
DOI: 10.1111/j.1749-6632.1999.tb07848.x

Genes

APOE
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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