Article
Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2006
Nakajima Takeshi, Maekita Takao, Oda Ichiro, Gotoda Takuji, Yamamoto Seiichiro, Umemura Satoshi, Ichinose Masao, Sugimura Takashi, Ushijima Toshikazu, Saito Daizo
Abstract excerpt
BACKGROUND: Helicobacter pylori infection potently induces methylation of CpG islands in gastric mucosae, which is considered to decrease to a certain level after active H. pylori infection discontinues. Noncancerous gastric mucosae of H. pylori-negative cases with a gastric cancer had higher methylation levels than those of H. pylori-negative healthy individuals. Here, using cases with multiple gastric cancers,...
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