The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae.

doi:10.1002/ijc.24018

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Article

The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae.

International journal of cancer - 15 Feb 2009

Nakajima Takeshi, Yamashita Satoshi, Maekita Takao, Niwa Tohru, Nakazawa Kazuyuki, Ushijima Toshikazu

Abstract excerpt

Aberrant DNA methylation is deeply involved in human cancers, but its inducers and targets are still mostly unclear. Helicobacter pylori infection was recently shown to induce aberrant methylation in gastric mucosae, and produce a predisposed field for cancerization. Here, we analyzed the presence of target genes in methylation induction by H. pylori and the mechanism for the gene specificity. Noncancerous...

Topics

Azacitidine
Cell Line, Tumor
CpG Islands
DNA (Cytosine-5-)-Methyltransferases
DNA Methylation
Decitabine
Epigenesis, Genetic
Gastric Mucosa
Genetic Predisposition to Disease
Helicobacter Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Helicobacter pylori

Humans

Promoter Regions, Genetic

RNA, Messenger

Reverse Transcriptase Polymerase Chain Reaction

Sulfites

Source

Open in PubMed

Identifiers

PMID: 19035455
DOI: 10.1002/ijc.24018

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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