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Article

DNA methylation accumulation in gastric mucosa adjacent to cancer after Helicobacter pylori eradication.

International journal of cancer - 1 Jan 2019

Tahara Sayumi, Tahara Tomomitsu, Horiguchi Noriyuki, Kato Takema, Shinkai Yasuko, Yamashita Hiromi, Yamada Hyuga, Kawamura Tomohiko, Terada Tsuyoshi, Okubo Masaaki, Nagasaka Mitsuo, Nakagawa Yoshihito, Shibata Tomoyuki, Yamada Seiji, Urano Makoto, Tsukamoto Tetsuya, Kurahashi Hiroki, Kuroda Makoto, Ohmiya Naoki

Abstract excerpt

Molecular irreversibleness with Helicobacter pylori (H. pylori) infection might have a role in gastric tumorigenesis after H. pylori eradication. We performed comprehensive DNA methylation profiling of gastric mucosa after H. pylori eradication with or without gastric cancer. Using four different groups of biopsies obtained from gastric body without history of H. pylori infection (Hp-), gastric body without...

Topics

Anti-Bacterial Agents
Biopsy
Cell Transformation, Neoplastic
CpG Islands
DNA Methylation
Female
Gastric Mucosa
Genetic Predisposition to Disease
Helicobacter Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Helicobacter pylori

Humans

Male

Middle Aged

Stomach Neoplasms

Telomere Shortening

Source

Identifiers

PMID: 29978464
DOI: 10.1002/ijc.31667

Genes

DNMT1
IGF2
MYOD1
PRDM5
RORA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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