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Role of <i>Helicobacter pylori</i> infection in aberrant DNA methylation along multistep gastric carcinogenesis

18 Feb 2010

Abstract excerpt

CpG island hypermethylation is frequently found during gastric carcinogenesis. We investigated methylation profiles of p16, LOX, HAND1, THBD, p41ARC, and APC along multistep gastric carcinogenesis and determined their association with Helicobacter pylori infection. Methylation levels in these six genes were evaluated in noncancerous gastric biopsy specimens using quantitative methylation-specific PCR in 459...

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PMID: 20345486
DOI: 10.1111/j.1349-7006.2010.01535.x

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