Article
Parafibromin is a nuclear protein with a functional monopartite nuclear localization signal.
Oncogene - 22 Feb 2007
Bradley K J, Bowl M R, Williams S E, Ahmad B N, Partridge C J, Patmanidi A L, Kennedy A M, Loh N Y, Thakker R V
Abstract excerpt
Parafibromin is a nuclear protein with a tumour suppressor role in the development of non-hereditary and hereditary parathyroid carcinomas, and the hyperparathyroidism-jaw tumour (HPT-JT) syndrome, which is associated with renal and uterine tumours. Nuclear localization signal(s), (NLS(s)), of the 61 kDa parafibromin remain to be defined. Utilization of computer-prediction programmes, identified five NLSs (three...
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