Article
Nuclear export of the transcription factor NirA is a regulatory checkpoint for nitrate induction in Aspergillus nidulans.
Molecular and cellular biology - 1 Feb 2007
Bernreiter Andreas, Ramon Ana, Fernández-Martínez Javier, Berger Harald, Araújo-Bazan Lidia, Espeso Eduardo A, Pachlinger Robert, Gallmetzer Andreas, Anderl Ingund, Scazzocchio Claudio, Strauss Joseph
Abstract excerpt
NirA, the specific transcription factor of the nitrate assimilation pathway of Aspergillus nidulans, accumulates in the nucleus upon induction by nitrate. NirA interacts with the nuclear export factor KapK, which bridges an interaction with a protein of the nucleoporin-like family (NplA). Nitrate induction disrupts the NirA-KapK interaction in vivo, whereas KapK associates with NirA when this protein is exported...
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