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Essential Paralogous Proteins as Potential Antibiotic Multitargets in Escherichia coli

29 Nov 2022

Abstract excerpt

Many types of bacteria have gained resistance to existing antibiotics used in medicine today. Therefore, new antibiotics with novel mechanisms must continue to be developed. One tool to prevent the development of antibiotic resistance is for a single drug to target multiple processes in a bacterium so that more than one change must arise for resistance to develop. The work described here provides a comprehensive...

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PMID: 36445138
DOI: 10.1128/spectrum.02043-22

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