Article
Host susceptibility to tuberculosis: CARD15 polymorphisms in a South African population.
Molecular and cellular probes - 1 Apr 2007
Möller Marlo, Nebel Almut, Kwiatkowski Ruta, van Helden Paul D, Hoal Eileen G, Schreiber Stefan
Abstract excerpt
Tuberculosis (TB) is one of the leading causes of death worldwide. The nucleotide-binding oligomerisation domain 2 protein (NOD2) has recently been recognised as a non-redundant recognition mechanism of Mycobacterium tuberculosis. The caspase recruitment domain-containing protein 15 gene (CARD15), which encodes the NOD2 protein, is a susceptibility gene for Crohn's disease (CD), a granulomatous, chronic...
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