Article
Large BRCA1 and BRCA2 genomic rearrangements in Malaysian high risk breast-ovarian cancer families.
Breast cancer research and treatment - 1 Nov 2010
Kang Peter, Mariapun Shivaani, Phuah Sze Yee, Lim Linda Shushan, Liu Jianjun, Yoon Sook-Yee, Thong Meow Keong, Mohd Taib Nur Aishah, Yip Cheng Har, Teo Soo-Hwang
Abstract excerpt
Early studies of genetic predisposition due to the BRCA1 and BRCA2 genes have focused largely on sequence alterations, but it has now emerged that 4-28% of inherited mutations in the BRCA genes may be due to large genomic rearrangements of these genes. However, to date, there have been relatively few studies of large genomic rearrangements in Asian populations. We have conducted a full sequencing and large...
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