Article
Analysis of BRCA1and BRCA2 large genomic rearrangements in Sri Lankan familial breast cancer patients and at risk individuals.
BMC research notes - 6 Jun 2014
De Silva Sumadee, Tennekoon Kamani Hemamala, Karunanayake Eric Hamilton, Amarasinghe Indrani, Angunawela Preethika
Abstract excerpt
BACKGROUND: Majority of mutations found to date in the BRCA1/BRCA2 genes in breast and/or ovarian cancer families are point mutations or small insertions and deletions scattered over the coding sequence and splice junctions. Such mutations and sequence variants of BRCA1 and BRCA2 genes were previously identified in a group of Sri Lankan breast cancer patients. Large genomic rearrangements have been characterized...
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