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Article

Functional and phenotypic differences between glioblastoma multiforme-derived and normal human brain endothelial cells.

Journal of neurosurgery - 1 Apr 2005

Charalambous Christiana, Hofman Florence M, Chen Thomas C

Abstract excerpt

OBJECT: Glioblastomas multiforme (GBMs) are hypervascular tumors characterized by endothelial cell (EC) proliferation. There is increasing evidence that ECs that infiltrate systemic tumors are different from normal blood vessel cells; whether this difference is seen in the central nervous system between GBM and normal brain tissue is not known. The goal of this investigation was to characterize and compare the...

Topics

Apoptosis
Brain
Brain Neoplasms
Cell Movement
Cell Proliferation
Endothelial Cells
Endothelin-1
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Glioblastoma
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Situ Nick-End Labeling

Neovascularization, Pathologic

Phenotype

Tumor Cells, Cultured

Vascular Endothelial Growth Factor A

Source

Identifiers

PMID: 15871513
DOI: 10.3171/jns.2005.102.4.0699

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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