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Article

Migration inhibitory factor mediates angiogenesis via mitogen-activated protein kinase and phosphatidylinositol kinase.

Circulation research - 22 Aug 2003

Amin M Asif, Volpert Olga V, Woods James M, Kumar Pawan, Harlow Lisa A, Koch Alisa E

Abstract excerpt

In this study, we investigated the effects of migration inhibitory factor (rhMIF) on angiogenesis-related signaling cascades and apoptosis in human endothelial cells (ECs). We show that in vitro rhMIF induces migration and tube formation in Matrigel of human dermal microvascular endothelial cells (HMVECs), with potency comparable to that of basic fibroblast growth factor. In vivo, rhMIF induces angiogenesis in...

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Identifiers

PMID: 12881477
DOI: 10.1161/01.RES.0000087641.56024.DA

Genes

MIF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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