Article
Structural and immunological correlations between the variable blocks of the VAR2CSA domain DBL6ε from two Plasmodium falciparum parasite lines.
Journal of molecular biology - 27 May 2013
Gangnard Stéphane, Badaut Cyril, Ramboarina Stéphanie, Baron Bruno, Ramdani Tarik, Gamain Benoît, Deloron Philippe, Lewit-Bentley Anita, Bentley Graham A
Abstract excerpt
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), a family of adhesins of the falciparum species of the malaria parasite, is exposed on the surface of the infected erythrocyte. In general, only one PfEMP1 variant is expressed at a time but switching between variants occurs, changing both host-cell receptor specificity and serotype. The PfEMP1 variant VAR2CSA causes sequestration of infected...
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