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Article

Nuclear export modulates the cytoplasmic Sir2 homologue Hst2.

EMBO reports - 1 Dec 2006

Wilson Jeanne M, Le Viet Q, Zimmerman Collin, Marmorstein Ronen, Pillus Lorraine

Abstract excerpt

Modulating transcription factors is crucial to executing sophisticated gene expression programs. The silent information regulator 2 (Sir2) family of NAD-dependent protein deacetylases influences transcription by targeting proteins such as histones, p53 and forkhead-box family transcription factors. Although apparently cytoplasmic, both mammalian SIRT2 and its yeast orthologue Hst2 have been implicated in...

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Share to Active Transport, Cell Nucleus
Share to Cytoplasm
Share to Gene Expression Regulation, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylases

Share to Nuclear Export Signals

Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Source

Open in PubMed Open full text

Identifiers

PMID: 17110954
DOI: 10.1038/sj.embor.7400829
PMCID: PMC1794688

Genes

SIRT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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