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Article

Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the induction of Langerhans cell maturation.

European journal of immunology - 1 Dec 2006

Fukunaga Atsushi, Nagai Hiroshi, Yu Xijun, Oniki Shuntaro, Okazawa Hideki, Motegi Sei-ichiro, Suzuki Ryuji, Honma Nakayuki, Matozaki Takashi, Nishigori Chikako, Horikawa Tatsuya

Abstract excerpt

Recently, we reported that Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 (SHPS-1) plays an important role in the migration of Langerhans cells (LC). Here, we show that SHPS-1 is involved in the maturation of LC. Immunofluorescence analysis on epidermal sheets for I-A or CD86 revealed that LC maturation induced by 2,4-dinitro-1-fluorobenzene (DNFB) or by TNF-alpha was inhibited by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17109464
DOI: 10.1002/eji.200635864

Genes

CCR7
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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