Article
Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity.
Pharmacogenetics and genomics - 1 Dec 2006
Dahlman Ingrid, Nilsson Maria, Jiao Hong, Hoffstedt Johan, Lindgren Cecilia M, Humphreys Keith, Kere Juha, Gustafsson Jan-Ake, Arner Peter, Dahlman-Wright Karin
Abstract excerpt
OBJECTIVE: LXRA and LXRB genes regulate adiposity, energy dissipation, as well as glucose and lipid homeostasis in mice. We investigated the LXR genes in human obesity. METHODS: LXRA and LXRB mRNAs were quantified in abdominal subcutaneous adipose tissue of obese and nonobese women. The LXRA and LXRB genes were screened for polymorphisms and common single nucleotide polymorphisms genotyped in obese and nonobese...
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