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Article

SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid.

Pharmacogenetics and genomics - 1 Dec 2006

Pasanen Marja K, Neuvonen Mikko, Neuvonen Pertti J, Niemi Mikko

Abstract excerpt

BACKGROUND AND OBJECTIVE: Organic anion transporting polypeptide 1B1 (OATP1B1) is an uptake transporter located at the sinusoidal membrane of human hepatocytes. This study aimed to investigate the effects of genetic polymorphism in the SLCO1B1 gene encoding OATP1B1 on the pharmacokinetics of simvastatin. METHODS: Four healthy volunteers with the homozygous SLCO1B1 c.521CC genotype, 12 with the heterozygous...

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Identifiers

PMID: 17108811
DOI: 10.1097/01.fpc.0000230416.82349.90

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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