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Article

Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.

Journal of clinical pharmacology - 1 Jun 2018

Wagner Jonathan B, Abdel-Rahman Susan, Van Haandel Leon, Gaedigk Andrea, Gaedigk Roger, Raghuveer Geetha, Kauffman Ralph, Leeder J Steven

Abstract excerpt

This study investigated the impact of allelic variation in SLCO1B1, a gene encoding for the liver-specific solute carrier organic anion transporter family member 1B1 protein (SLCO1B1), on simvastatin and simvastatin acid (SVA) systemic exposure in children and adolescents. Participants (8-20 years old) with at least 1 variant SLCO1B1 c.521T>C allele (521TC, n = 15; 521CC, n = 2) and 2 wild-type alleles (521TT,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

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Share to Polymorphism, Genetic

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Identifiers

PMID: 29469964
DOI: 10.1002/jcph.1080

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