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Article

The effect of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and 2-hydroxyatorvastatin in healthy Chinese people.

Die Pharmazie - 1 Jun 2017

Wang Yaqin, Tian Yingying, Lv Peiyu, Chen Lulu, Luo Wei, Jing Xian, Li Hui, Tan Zhirong, Wang Yicheng, Zhou Honghao, Ouyang Dong-Sheng

Abstract excerpt

The pharmacokinetics of statins show substantial inter-subject variability. Increasing systemic exposure of statins may lead to adverse drug reactions such as myopathy. The variation in statin pharmacokinetics is partly explained by genetic factors. OATP1B1, coded by SLCO1B1 transports a large number of therapeutic drugs, such as atorvastatin. Here we investigated the effect of SLCO1B1 polymorphism on the...

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PMID: 29442027
DOI: 10.1691/ph.2017.6944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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