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Article

SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid.

Pharmacogenetics and genomics - 1 Aug 2015

Tornio Aleksi, Vakkilainen Juha, Neuvonen Mikko, Backman Janne T, Neuvonen Pertti J, Niemi Mikko

Abstract excerpt

OBJECTIVE: Organic anion transporting polypeptide 1B1 (OATP1B1, encoded by SLCO1B1 gene) is a hepatic uptake transporter, and its genetic variability is associated with pharmacokinetics and muscle toxicity risk of simvastatin. We examined the possible effects of variations in the SLCO1B1 gene on the pharmacokinetics of lovastatin in a prospective genotype panel study. PARTICIPANTS AND METHODS: Seven healthy...

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Source

Identifiers

PMID: 26020121
DOI: 10.1097/FPC.0000000000000148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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