Article
Transcriptional activation of the human stress-inducible transcriptional repressor ATF3 gene promoter by p53.
Biochemical and biophysical research communications - 11 Oct 2002
Zhang Chun, Gao Choungfeng, Kawauchi Junya, Hashimoto Yoshinori, Tsuchida Nobuo, Kitajima Shigetaka
Abstract excerpt
Activating transcription factor 3 (ATF3) is an immediate early response gene that is induced in cells exposed to a variety of stress stimuli. In this report, upon exposure of cells to ultraviolet (UV) or proteasome inhibitor MG132, ATF3 protein was induced more efficiently in cells with intact p53 allele than in those with null mutant p53 allele. In Saos-2 cells harboring the temperature-sensitive mutant...
Topics
- Activating Transcription Factor 3
- Alleles
- Blotting, Western
- Cysteine Endopeptidases
- Cysteine Proteinase Inhibitors
- Genes, Reporter
- Genes, p53
- Humans
- Leupeptins
- Models, Genetic