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Article

Mutational analysis of action of mitochondrial fusion factor mitofusin-2.

Journal of cell science - 15 Jul 2005

Honda Shinji, Aihara Takeshi, Hontani Masayasu, Okubo Katsuhiko, Hirose Shigehisa

Abstract excerpt

Mitofusin-2 (Mfn2) is an essential component of mitochondrial fusion machinery, but its molecular mechanism of action is not clear. We found that a Mfn2 deletion mutant lacking two transmembrane spans (Mfn(DeltaTM)) acts as a dominant-negative mutant and blocks mitochondrial fusion. Furthermore,...

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PMID: 15985463
DOI: 10.1242/jcs.02449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15985463-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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