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Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins

30 Dec 2015

Abstract excerpt

Mitochondria are highly dynamic subcellular organelles participating in many signaling pathways such as antiviral innate immunity and cell death cascades. Here we found that mitochondrial fusion was impaired in dengue virus (DENV) infected cells. Two mitofusins (MFN1 and MFN2), which mediate mitochondrial fusion and participate in the proper function of mitochondria, were cleaved by DENV protease NS2B3. By...

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PMID: 26717518
DOI: 10.1371/journal.ppat.1005350

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