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Article

PfClpC Is an Essential Clp Chaperone Required for Plastid Integrity and Clp Protease Stability in Plasmodium falciparum.

Cell reports - 14 Nov 2017

Florentin Anat, Cobb David W, Fishburn Jillian D, Cipriano Michael J, Kim Paul S, Fierro Manuel A, Striepen Boris, Muralidharan Vasant

Abstract excerpt

The deadly malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid, known as the apicoplast, that functions to produce essential metabolites, and drugs that target the apicoplast are clinically effective. Several prokaryotic caseinolytic protease (Clp) genes have been identified in the Plasmodium genome. Using phylogenetic analysis, we focused on the Clp members that may form a regulated...

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Identifiers

PMID: 29141210
DOI: 10.1016/j.celrep.2017.10.081
PMCID: PMC5726808

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IPP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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