Article
Development of rheumatoid arthritis is not associated with two polymorphisms in the Crohn's disease gene CARD15.
Rheumatology (Oxford, England) - 1 Feb 2003
Steer S, Fisher S A, Fife M, Cuthbert A, Newton J, Wordsworth P, Lewis C M, Mathew C G, Lanchbury J S
Abstract excerpt
INTRODUCTION: It has been proposed that genetic susceptibility loci for rheumatoid arthritis (RA) may be shared with other autoimmune/inflammatory diseases. Recently, common variation in the CARD15 (NOD2) gene on chromosome 16q12 has been associated with Crohn's disease (CD) in several independent populations. CARD15 is an excellent functional and positional candidate gene for RA. METHODS: Genomic DNA was...
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