Article
Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase kappa in colorectal cancer.
Oncogene - 17 May 2007
Lemée F, Bavoux C, Pillaire M J, Bieth A, Machado C R, Pena S D, Guimbaud R, Selves J, Hoffmann J S, Cazaux C
Abstract excerpt
The low-fidelity DNA polymerases thought to be specialized in DNA damage processing are frequently misregulated in cancers. We show here that DNA polymerase kappa (polkappa), prone to replicate across oxidative and aromatic adducts and known to function in nucleotide excision repair (NER), is downregulated in colorectal tumour biopsies. Contrary to the replicative poldelta and polalpha, for which only activating...
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