Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular determinants of permeation through the cation channel TRPM6.

Cell calcium - 1 Jun 2007

Topala Catalin N, Groenestege Wouter Tiel, Thébault Stéphanie, van den Berg Dennis, Nilius Bernd, Hoenderop Joost G, Bindels René J

Abstract excerpt

TRPM6 and its closest relative TRPM7 are members of the Transient Receptor Potential Melastatin (TRPM) subfamily of cation channels and are known to be Mg2+ permeable. By aligning the sequence of the putative TRPM6 pore with the pore sequences of the other subfamily members, we located in the loop between the fifth and the sixth transmembrane domain, a stretch of amino acids residues, 1028GEIDVC1033, as the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cations
Share to Ion Transport
Share to Magnesium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Patch-Clamp Techniques

Share to Sequence Alignment

Share to Sodium

Share to Transfection

Share to TRPM Cation Channels

Source

Identifiers

PMID: 17098283
DOI: 10.1016/j.ceca.2006.10.003

Genes

TRPM6
TRPM7
TRPM1
TRPM3
TRPM4
TRPM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular determinants of permeation through the cation channel TRPM6.PMID 17098283Read ↗

The selectivity filter of the cation channel TRPM4.Semantic proximity Read ↗

Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7.Semantic proximity Read ↗

TRPM6.Semantic proximity Read ↗

The transient receptor potential superfamily of ion channels.Semantic proximity Read ↗

Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family.Semantic proximity Read ↗

Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions.Semantic proximity Read ↗

Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia.Semantic proximity Read ↗

Negatively charged amino acids near and in transient receptor potential (TRP) domain of TRPM4 channel are one determinant of its Ca2+ sensitivity.Semantic proximity Read ↗

Conserved cysteine residues in the pore region are obligatory for human TRPM2 channel function.Semantic proximity Read ↗

TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions.Semantic proximity Read ↗

TRPM1: new trends for an old TRP.Semantic proximity Read ↗

The region adjacent to the C-end of the inner gate in transient receptor potential melastatin 8 (TRPM8) channels plays a central role in allosteric channel activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.