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Article

Interactions between HIV-1 Gag molecules in solution: an inositol phosphate-mediated switch.

Journal of molecular biology - 19 Jan 2007

Datta Siddhartha A K, Zhao Zhuojun, Clark Patrick K, Tarasov Sergey, Alexandratos Jerry N, Campbell Stephen J, Kvaratskhelia Mamuka, Lebowitz Jacob, Rein Alan

Abstract excerpt

Retrovirus particle assembly is mediated by the Gag protein. Gag is a multi-domain protein containing discrete domains connected by flexible linkers. When recombinant HIV-1 Gag protein (lacking myristate at its N terminus and the p6 domain at its C terminus) is mixed with nucleic acid, it assembles into virus-like particles (VLPs) in a fully defined system in vitro. However, this assembly is defective in that the...

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Identifiers

PMID: 17098251
DOI: 10.1016/j.jmb.2006.10.072
PMCID: PMC1829305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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