Article
Expression of multidrug resistance gene mdr1 mRNA in a subset of normal bone marrow cells.
British journal of haematology - 1 Jun 1992
Marie J P, Brophy N A, Ehsan M N, Aihara Y, Mohamed N A, Cornbleet J, Chao N J, Sikic B I
Abstract excerpt
The multidrug resistance gene mdr1, encoding P-glycoprotein (P-gp), can be expressed at high levels in tumour cells derived from normal tissues with constitutive high expression of this gene. In myelogenous leukaemia, the incidence of increased expression of mdr1 gene contrasts with the low expression of this gene in normal bone marrow (b.m.). To detect cells expressing mdr1 gene in normal and post-chemotherapy...
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