Article
Polymorphism in the p2x7 gene increases susceptibility to extrapulmonary tuberculosis in Turkish children.
The Pediatric infectious disease journal - 1 Aug 2010
Tekin Deniz, Kayaalti Zeliha, Dalgic Nazan, Cakir Erkan, Soylemezoglu Tulin, Isin Kutlubay Busra, Aydin Kilic Betul
Abstract excerpt
The P2X7 gene polymorphisms have been linked to increased risk for pulmonary and extrapulmonary tuberculosis in some populations. In this study, the genotype and allelic frequencies 1513A-->C variant within the P2X7 gene was significantly higher than in the healthy controls (P = 0.035, P = 0.041). This is the first study demonstrating that the 1513A-->C polymorphism is associated with extrapulmonary tuberculosis...
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