Article
The LRC haplotype project: a resource for killer immunoglobulin-like receptor-linked association studies.
Tissue antigens - 1 Nov 2006
Horton R, Coggill P, Miretti M M, Sambrook J G, Traherne J A, Ward R, Sims S, Palmer S, Sehra H, Harrow J, Rogers J, Carrington M, Trowsdale J, Beck S
Abstract excerpt
There is increasing evidence for epistatic interactions between gene products (e.g. KIR) encoded within the Leukocyte Receptor Complex (LRC) with those (e.g. HLA) of the Major Histocompatibility Complex (MHC), resulting in susceptibility to disease. Identification of such associations at the DNA level requires comprehensive knowledge of the genetic variation and haplotype structure of the underlying loci. The LRC...
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