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Article

Impact of CYP2D6*10 on H1-antihistamine-induced hypersomnia.

European journal of clinical pharmacology - 1 Dec 2006

Saruwatari Junji, Matsunaga Masayuki, Ikeda Kazuyuki, Nakao Masashi, Oniki Kentaro, Seo Takayuki, Mihara Shuichi, Marubayashi Toru, Kamataki Tetsuya, Nakagawa Kazuko

Abstract excerpt

OBJECTIVE: This study investigated the relevance of the cytochrome P450 (CYP) 2D6 genotype to the adverse drug reactions (ADRs) of H1-antihistamines and the level of sedation. METHODS: Japanese participants in a health screening program were asked to describe any past history of ADRs. Any subjects reporting ADRs induced by H1-antihistamines were then individually interviewed and defined as cases. Excessive...

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PMID: 17089107
DOI: 10.1007/s00228-006-0210-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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