Article
Effects of the CYP2D6*10 allele on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole, in Japanese patients with schizophrenia.
Therapeutic drug monitoring - 1 Feb 2011
Suzuki Takeshi, Mihara Kazuo, Nakamura Akifumi, Nagai Goyo, Kagawa Shoko, Nemoto Kenji, Ohta Ikuya, Arakaki Hajime, Uno Tsukasa, Kondo Tsuyoshi
Abstract excerpt
The CYP2D6*10(*10) allele that causes decreased CYP2D6 activity is present in Asians with a high frequency of approximately 50%. We studied the effects of the *10 allele on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole. The subjects were 63 Japanese patients with schizophrenia who had only the wild-type or *10 alleles. Twenty-seven patients were homozygous...
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