Article
Effects of genetic polymorphisms of CYP2D6, CYP3A5, and ABCB1 on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole, in Japanese patients with schizophrenia.
Therapeutic drug monitoring - 1 Oct 2014
Suzuki Takeshi, Mihara Kazuo, Nakamura Akifumi, Kagawa Shoko, Nagai Goyo, Nemoto Kenji, Kondo Tsuyoshi
Abstract excerpt
BACKGROUND: We studied the effects of various factors, including genetic polymorphisms of the cytochrome P450 (CYP) 2D6, CYP3A5, and ABCB1, age, gender, and smoking habit on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole, in 89 patients with schizophrenia (46 males, 43 females). METHODS: All patients had been receiving fixed doses of aripiprazole for at least...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.