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Article

Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.

Molecular cancer therapeutics - 1 Nov 2006

Ikediobi Ogechi N, Davies Helen, Bignell Graham, Edkins Sarah, Stevens Claire, O'Meara Sarah, Santarius Thomas, Avis Tim, Barthorpe Syd, Brackenbury Lisa, Buck Gemma, Butler Adam, Clements Jody, Cole Jennifer, Dicks Ed, Forbes Simon, Gray Kristian, Halliday Kelly, Harrison Rachel, Hills Katy, Hinton Jonathan, Hunter Chris, Jenkinson Andy, Jones David, Kosmidou Vivienne, Lugg Richard, Menzies Andrew, Mironenko Tatiana, Parker Adrian, Perry Janet, Raine Keiran, Richardson David, Shepherd Rebecca, Small Alex, Smith Raffaella, Solomon Helen, Stephens Philip, Teague Jon, Tofts Calli, Varian Jennifer, Webb Tony, West Sofie, Widaa Sara, Yates Andy, Reinhold William, Weinstein John N, Stratton Michael R, Futreal P Andrew, Wooster Richard

Abstract excerpt

The panel of 60 human cancer cell lines (the NCI-60) assembled by the National Cancer Institute for anticancer drug discovery is a widely used resource. The NCI-60 has been characterized pharmacologically and at the molecular level more extensively than any other set of cell lines. However, no systematic mutation analysis of genes causally implicated in oncogenesis has been reported. This study reports the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17088437
DOI: 10.1158/1535-7163.MCT-06-0433
PMCID: PMC2705832

Genes

APC
BRAF
CTNNB1
HRAS
KRAS
NRAS
PTEN
SMAD4
STK11
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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