Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NCI-60 whole exome sequencing and pharmacological CellMiner analyses.

PloS one - 1 Jan 2014

Reinhold William C, Varma Sudhir, Sousa Fabricio, Sunshine Margot, Abaan Ogan D, Davis Sean R, Reinhold Spencer W, Kohn Kurt W, Morris Joel, Meltzer Paul S, Doroshow James H, Pommier Yves

Abstract excerpt

Exome sequencing provides unprecedented insights into cancer biology and pharmacological response. Here we assess these two parameters for the NCI-60, which is among the richest genomic and pharmacological publicly available cancer cell line databases. Homozygous genetic variants that putatively affect protein function were identified in 1,199 genes (approximately 6% of all genes). Variants that are either...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Data Mining

Share to Databases, Factual

Share to Genome

Share to Genomics

Share to Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 25032700
DOI: 10.1371/journal.pone.0101670
PMCID: PMC4102467

Genes

BRAF
EGFR
ERBB2
MTOR
RAD52
NOM1
STAT2
TLL2
TSC2
XDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NCI-60 whole exome sequencing and pharmacological CellMiner analyses.PMID 25032700Read ↗

Using CellMiner 1.6 for Systems Pharmacology and Genomic Analysis of the NCI-60.Semantic proximity Read ↗

The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology.Semantic proximity Read ↗

rcellminer: exploring molecular profiles and drug response of the NCI-60 cell lines in RSemantic proximity Read ↗

RNA Sequencing of the NCI-60: Integration into CellMiner and CellMiner CDBSemantic proximity Read ↗

MUSTARD-a comprehensive resource of mutation-specific therapies in cancer.Semantic proximity Read ↗

Cancer driver genes and opportunities for precision oncology revealed by whole genome sequencing 10,478 cancersSemantic proximity Read ↗

Data Mining Approaches for Genomic Biomarker Development: Applications Using Drug Screening Data from the Cancer Genome Project and the Cancer Cell Line Encyclopedia.Semantic proximity Read ↗

CellMinerCDB for Integrative Cross-Database Genomics and Pharmacogenomics Analyses of Cancer Cell LinesSemantic proximity Read ↗

CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer.Semantic proximity Read ↗

Individualized genetic network analysis reveals new therapeutic vulnerabilities in 6,700 cancer genomes.Semantic proximity Read ↗

Interactive webtool for analyzing drug sensitivity and resistance associated with genetic signatures of cancer cell lines.Semantic proximity Read ↗

Cancer driver genes and opportunities for precision oncology revealed by whole genome sequencing 10,478 cancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.