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Article

<i>Scotin</i>, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

22 Jul 2002

Abstract excerpt

p53 is a transcription factor that induces growth arrest or apoptosis in response to cellular stress. To identify new p53-inducible proapoptotic genes, we compared, by differential display, the expression of genes in spleen or thymus of normal and p53 nullizygote mice after gamma-irradiation of whole animals. We report the identification and characterization of human and mouse Scotin homologues, a novel gene...

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PMID: 12135983
DOI: 10.1083/jcb.200203006

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