Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells.

Oncogene - 3 May 2007

Ivanov I, Lo K C, Hawthorn L, Cowell J K, Ionov Y

Abstract excerpt

Inhibition of the nonsense-mediated decay (NMD) mechanism in cells results in stabilization of transcripts carrying premature translation termination codons. A strategy referred to as gene identification by NMD inhibition (GINI) has been proposed to identify genes carrying nonsense mutations. Genes containing frameshift mutations in colon cancer cell line have been identified using a modified version of GINI. To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caffeine
Share to Codon, Nonsense
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to RNA, Antisense

Share to RNA Interference

Share to RNA Stability

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 17086209
DOI: 10.1038/sj.onc.1210098

Genes

FXR1
NCOR1
PHF14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells.PMID 17086209Read ↗

Identification of ARHGEF17, DENND2D, FGFR3, and RB1 mutations in melanoma by inhibition of nonsense-mediated mRNA decay.Semantic proximity Read ↗

The application of nonsense-mediated mRNA decay inhibition to the identification of breast cancer susceptibility genes.Semantic proximity Read ↗

A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay.Semantic proximity Read ↗

Nonsense-mediated RNA decay and its bipolar function in cancer.Semantic proximity Read ↗

Identification of inactivating mutations in the JAK1, SYNJ2, and CLPTM1 genes in prostate cancer cells using inhibition of nonsense-mediated decay and microarray analysis.Semantic proximity Read ↗

SMG1:SMG8:SMG9-complex integrity maintains robustness of nonsense-mediated mRNA decaySemantic proximity Read ↗

Combining Translation Readthrough Inducing Drugs and Nonsense Mediated Decay Pathway Inhibition to Rescue of CFTRW1282X in Cystic Fibrosis Cell Model SystemSemantic proximity Read ↗

Inhibition of nonsense-mediated mRNA decay reduces the tumorigenicity of human fibrosarcoma cellsSemantic proximity Read ↗

CRISPR-Based Screen Links an Inhibitor of Nonsense-Mediated Decay to eIF4A3 Target Engagement.Semantic proximity Read ↗

Nonsense mediated decay resistant mutations are a source of expressed mutant proteins in colon cancer cell lines with microsatellite instability.Semantic proximity Read ↗

MicroRNA, SND1, and alterations in translational regulation in colon carcinogenesisSemantic proximity Read ↗

A non-invasive diagnostic assay for rapid detection and characterization of aberrant mRNA-splicing by nonsense mediated decay inhibition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.