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Article

The application of nonsense-mediated mRNA decay inhibition to the identification of breast cancer susceptibility genes.

BMC cancer - 15 Jun 2012

Johnson Julie K, Waddell Nic, Chenevix-Trench Georgia

Abstract excerpt

BACKGROUND: Identification of novel, highly penetrant, breast cancer susceptibility genes will require the application of additional strategies beyond that of traditional linkage and candidate gene approaches. Approximately one-third of inherited genetic diseases, including breast cancer susceptibility, are caused by frameshift or nonsense mutations that truncate the protein product 1. Transcripts harbouring...

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Identifiers

PMID: 22703186
DOI: 10.1186/1471-2407-12-246
PMCID: PMC3409022

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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