Article
Functional coupling between the two active sites during Tn 10 transposition buffers the mutation of sequences critical for DNA hairpin processing.
Molecular microbiology - 1 Dec 2006
Liu Danxu, Sewitz Sven, Crellin Paul, Chalmers Ronald
Abstract excerpt
DNA processing reactions often involve multiple components acting in concert to achieve the desired outcome. However, it is usually difficult to know how the components communicate and cooperate to orchestrate an ordered series of events. We address this question in the context of the Tn 10 transposition reaction, in which the DNA cleavage and joining events occur within a higher-order complex containing a...
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