Article
Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features.
Proceedings of the National Academy of Sciences of the United States of America - 14 Nov 2006
Batra Vinod K, Shock David D, Prasad Rajendra, Beard William A, Hou Esther W, Pedersen Lars C, Sayer Jane M, Yagi Haruhiko, Kumar Subodh, Jerina Donald M, Wilson Samuel H
Abstract excerpt
We have determined the crystal structure of the human base excision repair enzyme DNA polymerase beta (Pol beta) in complex with a 1-nt gapped DNA substrate containing a template N2-guanine adduct of the tumorigenic (-)-benzo[c]phenanthrene 4R,3S-diol 2S,1R-epoxide in the gap. Nucleotide insertion opposite this adduct favors incorrect purine nucleotides over the correct dCMP and hence can be mutagenic. The...
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