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The role of MKK1/2 kinase activity in human cytomegalovirus infection

1 Mar 2001

Abstract excerpt

Human cytomegalovirus infection of quiescent fibroblasts was found to induce a bi-phasic activation of mitogen-activated protein kinase (MAPK) kinase 1 and 2 (MKK1/2) and two of their downstream targets, extracellular signal regulated kinase 1 and 2 (ERK1/2), as determined by Western blot analysis using phospho-specific antibodies. Treatment of infected fibroblasts with U0126, a potent and specific inhibitor of...

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PMID: 11172089
DOI: 10.1099/0022-1317-82-3-493

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