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Article

Murine Coronavirus Delays Expression of a Subset of Interferon-Stimulated Genes

1 Apr 2010

Abstract excerpt

The importance of the type I interferon (IFN-I) system in limiting coronavirus replication and dissemination has been unequivocally demonstrated by rapid lethality following infection of mice lacking the alpha/beta IFN (IFN-alpha/beta) receptor with mouse hepatitis virus (MHV), a murine coronavirus. Interestingly, MHV has a cell-type-dependent ability to resist the antiviral effects of IFN-alpha/beta. In primary...

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PMID: 20357099
DOI: 10.1128/jvi.00211-10

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