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Article

The production of a diabetic mouse using constructs encoding porcine insulin promoter-driven mutant human hepatocyte nuclear factor-1alpha.

The Journal of reproduction and development - 1 Apr 2007

Watanabe Masahito, Umeyama Kazuhiro, Kawano Hiro-Omi, Izuno Naoko, Nagashima Hiroshi, Miki Keizaburo

Abstract excerpt

A diabetic mouse model was produced using a mutant human hepatocyte nuclear factor-1alpha gene (HNF1alphaP291fsinsC) regulated by the porcine insulin promoter. The functionality of two different constructs containing HNF1alphaP291fsinsC, termed PD1 and PD2 (cytomegalovirus enhancer minus and plus), were examined in transgenic mice. The blood glucose levels and body weights of the PD1 transgenic mice did not...

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Identifiers

PMID: 17077577
DOI: 10.1262/jrd.18068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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