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Article

Dominant-negative mutant hepatocyte nuclear factor 1alpha induces diabetes in transgenic-cloned pigs.

Transgenic research - 1 Oct 2009

Umeyama Kazuhiro, Watanabe Masahito, Saito Hitoshi, Kurome Mayuko, Tohi Sadaaki, Matsunari Hitomi, Miki Keizaburo, Nagashima Hiroshi

Abstract excerpt

Pigs have been recognized as an excellent biomedical model for investigating a variety of human health issues. We developed genetically modified pigs that exhibit the apparent symptoms of diabetes. Transgenic cloned pigs carrying a mutant human hepatocyte nuclear factor 1alpha gene, which is know...

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PMID: 19357985
DOI: 10.1007/s11248-009-9262-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19357985-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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