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Article

Gene knockout of the KCNJ8-encoded Kir6.1 K(ATP) channel imparts fatal susceptibility to endotoxemia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2006

Kane Garvan C, Lam Chen-Fuh, O'Cochlain Fearghas, Hodgson Denice M, Reyes Santiago, Liu Xiao-Ke, Miki Takashi, Seino Susumu, Katusic Zvonimir S, Terzic Andre

Abstract excerpt

Sepsis, the systemic inflammatory response to infection, imposes a high demand for bodily adaptation, with the cardiovascular response a key determinant of outcome. The homeostatic elements that secure cardiac tolerance in the setting of the sepsis syndrome are poorly understood. Here, in a model of acute septic shock induced by endotoxin challenge with Escherichia coli lipopolysaccharide (LPS), knockout of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17077304
DOI: 10.1096/fj.06-6349com

Genes

KCNJ8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Gene knockout of the KCNJ8-encoded Kir6.1 K(ATP) channel imparts fatal susceptibility to endotoxemia.PMID 17077304Read ↗

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