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Article

Loss-of-function mutations in the KCNJ8-encoded Kir6.1 K(ATP) channel and sudden infant death syndrome.

Circulation. Cardiovascular genetics - 1 Oct 2011

Tester David J, Tan Bi-Hua, Medeiros-Domingo Argelia, Song Chunhua, Makielski Jonathan C, Ackerman Michael J

Abstract excerpt

BACKGROUND: Approximately 10% of sudden infant death syndrome (SIDS) may stem from cardiac channelopathies. The KCNJ8-encoded Kir6.1 (K(ATP)) channel critically regulates vascular tone and cardiac adaptive response to systemic metabolic stressors, including sepsis. KCNJ8-deficient mice are prone to premature sudden death, particularly with infection. We determined the spectrum, prevalence, and function of KCNJ8...

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Identifiers

PMID: 21836131
DOI: 10.1161/CIRCGENETICS.111.960195
PMCID: PMC3281577

Genes

KCNJ8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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